Co-loaded lapatinib/PAB by ferritin nanoparticles eliminated ECM-detached cluster cells via modulating EGFR in triple-negative breast cancer

Abstract Cancer stem cell (CSC) cluster of triple-negative breast cancer (TNBC) is suggested to be responsible Dab Tools for therapy resistance, metastatic process and cancer recurrence, yet the sensitivity of CSC clusters of TNBC to ferroptosis remains elusive in a great measure.Current research revealed that epidermal growth factor receptor (EGFR

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Urgent distal pancreatectomy for intraperitoneal hemorrhage due to the spontaneous rupture of a pancreatic metastatic tumor from synovial sarcoma: a case report

Abstract Background Synovial sarcoma is a soft tissue malignancy that frequently affects the extremities, adjacent to the large joints.Synovial sarcoma has a high rate of distant metastasis; however, pancreatic metastasis is extremely rare, and to our knowledge, there has been no report of bleeding due to spontaneous tumor rupture.This study report

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Harmonization of rail profiles and wheel pair

The main difficulty of developing measures for complex evaluation of loading and increasing of resource of running gear parts performance is considering of differences of performance conditions of wheel-rail system.The article presents review of Russian and foreign experience on selection of shapes of carriage wheel profiles depending on the develo

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Mapping of mitral regurgitant defects by cardiovascular magnetic resonance in moderate or severe mitral regurgitation secondary to mitral valve prolapse

Abstract Purpose In mitral valve prolapse, determining whether the valve is suitable for surgical repair depends on the location and mechanism of regurgitation.We assessed whether cardiovascular magnetic resonance (CMR) could accurately identify prolapsing or flail mitral valve leaflets and regurgitant jet direction in patients with known Pet Suppl

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Artificial intelligence in neuro-oncology: advances and challenges in brain tumor diagnosis, prognosis, and precision treatment

Abstract This review delves into the most recent advancements in applying artificial intelligence (AI) within neuro-oncology, specifically emphasizing work on gliomas, a class of brain tumors that represent a significant global health issue.AI has brought transformative innovations to brain tumor management, utilizing imaging, histopathological, an

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